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Pneumococcal disease: meningitis

  • The case-fatality for pneumococcal meningitis is high.

  • Infection can cause damage to the brain and lead to permanent disability.


Pneumococcal disease

  • S. pneumoniae is the leading cause of bacterial meningitis in elderly persons. This study involved the surveillance of a population of 34 million people in the USA in 1986.

  • S. pneumoniae was the cause of nearly 40% of cases of meningitis among the 30 – 59 year old group, and of nearly 50% of the cases among elderly patients (aged > 60 years).

  • In western countries (where Hib vaccination programmes have been implemented for several years), S. pneumoniae is the most common cause of bacterial meningitis.


Epidemiology: invasive pneumococcal disease

  • Where vaccination programmes against Haemophilus influenzae type b (Hib) have been implemented, S. pneumoniae is now the most common cause of bacterial meningitis.

  • The case fatality rate for pneumococcal meningitis is high, particularly among adults.


Pneumococcal disease: medical management

  • Treatment usually begins before the aetiology of the disease is known. The choice of therapy should be governed by knowledge of local patterns of resistance.

  • Oral amoxycillin is often used to treat pneumonia in patients treated in the community. Hospitalised patients often receive multiple antibiotics administered intravenously (e.g. cephalosporin + erythromycin)

  • Because of antibiotic resistance, penicillin is also no longer the first line of treatment for suspected pneumococcal meningitis. A third-generation cephalosporin is often used now.



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